5 years ago

Total Synthesis of Biselide E, a Marine Polyketide

Total Synthesis of Biselide E, a Marine Polyketide
Takayuki Ohyoshi, Masami Okamura, Kazuaki Suzuki, Hideo Kigoshi, Shota Funakubo, Dai Kawamura, Ichiro Hayakawa, Yuto Onozaki
The total synthesis of biselide E, a marine polyketide isolated from the Okinawan ascidian, has been accomplished. The highlight of this approach is the use of the β-elimination reaction of the chloroacetoxy group for the construction of an unstable six-membered α,β,γ,δ-unsaturated lactone portion at the late stage of the total synthesis.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03009

DOI: 10.1021/acs.orglett.7b03009

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