Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
4 years ago

Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone Receptors

Photodynamic Oncotherapy Mediated by Gonadotropin-Releasing Hormone Receptors
Jincan Chen, Yongshuai Yang, Peng Xu, Mingdong Huang, Ping Hu, Zhuo Chen, Yuhua Jia
Here, we report photodynamic oncotherapies mediated by gonadotropin-releasing hormone (GnRH) receptors. We synthesized conjugates 1 and 2 by coupling zinc phthalocyanine (ZnPc) to GnRH analogues. Compared to unmodified ZnPc, conjugates 1 and 2 exhibited higher and more specific phototoxicities to breast cancer cells. Furthermore, the two conjugates demonstrated excellent antitumor efficacies in a breast cancer-grafted animal model. Biodistribution study suggested the high biosafety of conjugate 2 because of the low retention in brain and skin.

Publisher URL: http://dx.doi.org/10.1021/acs.jmedchem.7b01216

DOI: 10.1021/acs.jmedchem.7b01216

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.