Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Efficient One-pot Multifunctionalization of Alkynes en Route to α- Alkoxyketones, α-Thioketones and α-Thio Thioketals using an Umpolung Strategy

Efficient One-pot Multifunctionalization of Alkynes en Route to α- Alkoxyketones, α-Thioketones and α-Thio Thioketals using an Umpolung Strategy
Liming Zhang, Xu Zhou, Rongliang Zhai, Ting Liang
N-alkenoxypyridinium salts, generated from the corresponding activated alkynes using a gold(I) catalyst, showed unconventional umpolung activity. This umpolung strategy not only offers highly valuable and unprecedented alternatives for the synthesis of various α-alkoxyketones, α-thioketones and α-thio thioketals, but also has the potential of revolutionizing the enolate umpolung chemistry. More information can be found in the Communication by X. Zhou et al. (DOI: 10.1002/chem.201703087).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201703471

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