Chemistry - A European Journal
Chemistry - A European Journal
4 years ago

Designed Synthesis of Au/Fe3O4@C Janus Nanoparticles for Dual-Modal Imaging and Actively Targeted Chemo-Photothermal Synergistic Therapy of Cancer Cells

Designed Synthesis of Au/Fe3O4@C Janus Nanoparticles for Dual-Modal Imaging and Actively Targeted Chemo-Photothermal Synergistic Therapy of Cancer Cells
Lu Li, Chungang Wang, Manjie Zhang, Lingyu Zhang, Shengnan Li, Tingting Wang, Xiangjun Chen, Qi Zhang
A newly developed approach is presented for the fabrication of new generation of Janus nanoparticles (JNPs)—Au/Fe3O4@C. These JNPs were functionalized with amino-poly(ethylene glycol)thiol (NH2-PEG-SH) and folic acid (FA) on the exposed Au domains, whereas the mesoporous Fe3O4@C side served as the drug delivery vehicle of doxorubicin (DOX). The resultant FA-PEG-Au/Fe3O4@C JNPs were employed as a new theranostic agent for CT and MR imaging-guided actively targeted chemo-photothermal synergistic therapy of cancer cells. More information can be found in the Full Paper by L. Li, C. Wang et al. (DOI: 10.1002/chem.201703498).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201704227

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