4 years ago

Stick–Slip Motion of ssDNA over Graphene

Stick–Slip Motion of ssDNA over Graphene
Ernst Meyer, Enrico Gnecco, Rubén Pérez, Rémy Pawlak, Fernando Moreno-Herrero, J. G. Vilhena
We have performed molecular dynamics simulations of nanomanipulation experiments on short single-stranded DNA chains elastically driven on a graphene surface. After a brief transient, reproducible stick–slip cycles are observed on chains made by 10 units of thymine, cytosine, adenine, and guanine. The cycles have the periodicity of the graphene substrate, and take place via an intermediate stage, appearing as a dip in the sawtooth variations of lateral force recorded while the chains are manipulated. Guanine presents remarkable differences from the other bases, since a lower number of nucleotides are prone to stick to the substrate in this case. Nevertheless, the magnitudes of static friction and lateral stiffness are similar for all chains (30 pN and 0.7 N/m per adsorbed nucleotide respectively).

Publisher URL: http://dx.doi.org/10.1021/acs.jpcb.7b06952

DOI: 10.1021/acs.jpcb.7b06952

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