3 years ago

Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry

Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry
Jennifer M. Noto, Richard M. Peek

Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epithelial cells to drive carcinogenesis. In this issue of Cell Host & Microbe</i>, Tegtmeyer et al. (2017) show that a secreted bacterial protease disrupts apical-junctional complexes, paving the way for H. pylori to access the basolateral compartment and trigger pathogenesis.

Publisher URL: http://www.cell.com/cell-host-microbe/fulltext/S1931-3128(17)30403-1

DOI: 10.1016/j.chom.2017.09.014

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