Shigella Stays on the Move
Guanylate-binding proteins (GBPs) confer protection against intracellular pathogens. In this issue of Cell Host & Microbe</i>, Wandel et al. (2017) report that cytosolic Shigella becomes trapped within a GBP coat that prevents bacterial cell-to-cell spread. However, this defense mechanism is counteracted by the bacterial E3 ubiquitin ligase IpaH9.8.
Publisher URL: http://www.cell.com/cell-host-microbe/fulltext/S1931-3128(17)30402-X
DOI: 10.1016/j.chom.2017.09.013
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