Clinical Microbiology and Infection
Clinical Microbiology and Infection
5 years ago

In utero negativization of Zika virus in a case with serious Central Nervous System abnormalities

In utero negativization of Zika virus in a case with serious Central Nervous System abnormalities
To describe a case of a pregnant woman with Zika virus infection and severe fetal brain malformations. Methods Serial ultrasound measurements, fetal magnetic resonance imaging results, laboratory and amniocentesis results, and perinatal outcomes of the pregnant woman and her neonate are reported. Results Zika virus tested positive in amniotic fluid at 19 weeks while being negative at delivery. The newborn did not meet the case definition of congenital Zika virus syndrome because neither the Zika virus RNA nor immunoglobulin M antibodies were detected; however, prenatal brain lesions were confirmed after birth. Conclusions The presence of Zika virus in amniotic fluid plays a role in the diagnosis of Zika virus congenital syndrome.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305396

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