Clinical Microbiology and Infection
Clinical Microbiology and Infection
5 years ago

Clinical prediction rules used to rule out endocarditis must be assessed against a sensitive reference standard

This letter discusses an important limitation of the literature recently reviewed by Bai et al (Bai AD, Agarwal A, Steinberg M, et al. Clinical predictors and clinical prediction rules to estimate initial patient risk for infective endocarditis in Staphylococcus aureus bacteraemia: a systematic review and meta-analysis. Clin Microbiol Infect 2017. In press). Specifically we discuss the effect that low transoesophageal echocardiography usage on the reliability of the reference standard used in many of these studies, and outline the potential effect this might have on the reliability of the estimates of the diagnostic performance of the clinical prediction rules.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17305360

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