European Urology
European Urology
3 years ago

The Search for the Missing Heritability of Prostate Cancer

Scientists and clinicians at Johns Hopkins have been working since 1987 to uncover the genetic pathogenesis of prostate cancer. A patient query about the hereditary nature of the disease led to data collection on family history, followed by segregation and linkage analyses. Collaborative investigations using next-generation sequencing to identify genetic variants associated with prostate cancer risk have revealed the significance of HOXB13, BRCA 1/2, and DNA repair mutations.

Publisher URL: www.sciencedirect.com/science

DOI: S030228381730283X

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