Aging Cell
Aging Cell
5 years ago

Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK

Sian M. Henson, Emma S. Chambers, Elizabeth C. Carroll, Arne N. Akbar, Sussan Nourshargh, Robert W. J. Beal, Lauren A. Callender
Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contribute to age-associated inflammation. We found the CD8+ CD45RA+CD27− EMRA subset to be the most heterogeneous, with a population aligning with the naïve T cells and another with a closer association to the effector memory subset. However, despite the differing processes that give rise to these senescent CD8+ T cells once generated, they both adopt a unique secretory profile with no commonality to any other subset, aligning more closely with senescence than quiescence. Furthermore, we also show that the SASP observed in senescent CD8+ T cells is governed by p38 MAPK signalling.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/acel.12675

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