Prevalence and outcomes of cystic lesions of the transplant pancreas: The University of Wisconsin Experience

5 years ago

Prevalence and outcomes of cystic lesions of the transplant pancreas: The University of Wisconsin Experience

Dixon B Kaufman, Eric J Martinez, Jon S Odorico, Bridget Welch, Talal M Al-Qaoud, Glen Leverson, Robert R Redfield, Hans W Sollinger

Literature on the behavior of cystic lesions in pancreas transplants is scarce, and hence a better understanding is warranted. Data on recipients and their respective donors that underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after kidney between 1994-2015 were reviewed (n=1185). Cystic lesions of the transplant pancreas developed in 22 patients (1.8%): 12 pseudocysts, 2 cysts/remnants, 4 intraductal papillary mucinous neoplasms (IPMN), 2 adenocarcinomas, 1 low grade intraepithelial pancreatic neoplasia, and 1 case of polycystic kidney disease. The median size was 3.6cm (1.6-5.5cm), and occurred at a median time of 65.5mos (2-183mos) post transplant. The median age of the graft at time of diagnosis was 42yrs (25.7-54.5), with 17 of 22 grafts (77%) functioning at time of diagnosis. Triggers for investigation were elevations in pancreatic enzymes, re-admissions for abdominal pain, and incidentalomas. High resolution imaging and diagnostic biopsy/aspiration with ancillary tests were the main diagnostic tests. Most pseudocysts were managed by percutaneous drainage, and although no firm inference can be made from such a small series, we have observed that the behavior and management of IPMN and adenocarcinoma in the pancreas graft appears congruent to that of the native pancreas. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/ajt.14540