3 years ago

Gut microbiota as a therapeutic target for metabolic disorders.

Fujishiro, Yamamotoya, Yoneda, Okubo, Matsunaga, Ono, Sakoda, Nakatsu, Asano, Kushiyama, Ohno, Inoue
The prevalence of metabolic disorders has been rising worldwide, making the identification of factors affecting metabolic control more important than ever. Gut microbiota play a vital role not only in the digestion and absorption of nutrients, but also in homeostatic maintenance of host immunity, metabolism and the gut barrier. It was recently suggested that gut microbiota alterations contribute to the pathogenesis of metabolic disorders such as obesity, diabetes mellitus and non-alcoholic fatty liver disease. Possible causal links between gut microbiota and these metabolic disorders, as well as the underlying mechanisms, have been the focus of both clinical and basic research. Although further studies are needed, the gut microbiota represents a novel potential therapeutic target for a range of metabolic disorders. In this review, we discuss relationships between the gut microbiota and metabolic disorders, and also promising interventions such as prebiotics, probiotics, fecal microbiota transplantation, and other new treatment possibilities, focusing especially on recent human studies.

Publisher URL: http://doi.org/10.2174/0929867324666171009121702

DOI: 10.2174/0929867324666171009121702

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.