3 years ago

Vasopressin Versus Norepinephrine in Patients With Vasoplegic Shock After Cardiac Surgery: The VANCS Randomized Controlled Trial

Costa Auler, J. O. Jr, Lisboa, L. A., Filho, R. K., Strabelli, T. M., Dallan, L. O., Landoni, G., Zeferino, S., Piccioni, M. A., Souza, D. H., Rhodes, A., Sundin, M. R., Fernandes, F. L., de Almeida, J. P., Barbosa Gomes Galas, F. R., Gaiotto, F. A., Hajjar, L. A., Osawa, E. A., Pomerantzeff, P. M., Grande, S. M., Franco, R. A., Fukushima, J. T., Vincent, J. L., Camara, L., Park, C. L., Zambolim, C., Nakamura, R. E., Jatene, F. B., Rocha Ferreira, G. S., Melo, R. R., Santos, V. G., Gaiane, M. A., Gerent, A. M.
(Abstracted from Anesthesiology, 126(1):85–93, 2017) The purpose of this prospective, double-blind, randomized controlled trial was to gauge whether vasopressin is superior to norepinephrine in reducing postoperative complications in patients with vasoplegic syndrome. This complication, which presents in 5% to 25% of cardiac surgery patients, is characterized by low arterial pressure with either normal or elevated cardiac output but reduced systemic vascular resistance.
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