4 years ago

In vitro activity of Pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin-structure infections (SSSI).

Citron, Goldstein, Tyrrell, Leoncio
Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. MIC90s were as follows: B. fragilis, 16 μg/ml; other Bacteroidesfragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; and Porphyromonas spp., 64 μg/ml; P. acnes, 4 μg/ml; E. lenta and P. anaerobius, 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for SSSIs involving anaerobes.

Publisher URL: http://doi.org/10.1128/AAC.01401-17

DOI: 10.1128/AAC.01401-17

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.