3 years ago

Childhood Residential and Agricultural Pesticide Exposures in Relation to Adult Onset Rheumatoid Arthritis in Women.

D'Aloisio, Sandler, Parks
Farming and pesticide exposure may influence risk of rheumatoid arthritis (RA), but the role of early life pesticide exposures is not known. In the Sister Study, a national cohort of women ages 35-74 (enrolled 2004-2009), we examined childhood pesticide exposures in adult-onset RA. Cases (n = 424), reported at enrollment and confirmed by disease modifying anti-rheumatic drugs or steroid use for RA and ≥6 weeks bilateral joint swelling, were compared to 48,919 non-cases. Data included pesticide use at the longest childhood residence through age 14, farm residence of ≥12 months with agricultural pesticide exposures through age 18, and maternal farm experience. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age, race/ethnicity, education, smoking, and childhood socioeconomic factors. RA cases reported more frequent (monthly+) and direct (personal) residential pesticide use in childhood (ORs ranging from 1.1 for infrequent/indirect to 1.8 for frequent/direct; P-trend = 0.013). Compared to women with no residential farm history, odds of RA increased for those reporting a childhood-only farm residence with personal exposure to pesticides used on crops (OR = 1.8:95% CI: 1.1, 2.9) or livestock (OR = 2.0:95% CI: 1.2, 3.3). Our findings suggest adult-onset RA may be related to childhood exposures to residential and agricultural pesticides, and support further investigations of lifetime pesticide use in RA.

Publisher URL: http://doi.org/10.1093/aje/kwx224

DOI: 10.1093/aje/kwx224

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