Journal of Cell Biology (JCB)
Journal of Cell Biology (JCB)
4 years ago

Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI

Lu Li, Kun Liu, Jun Yin, Yun-Xiang Qi
This study aims to evaluate the efficacy of chemoradiotherapy for advanced cervical cancer using heat shock protein 70 (HSP70) combined with multimodal MRI. The protein expressions of HSP70 in biopsy specimens obtained from 101 patients with cervical cancer were detected by immunohistochemistry. Plain MRI scan, DWI, DCE-MR and MRS were performed before and after a period of six months of chemoradiotherapy. All patients were assigned into the complete response (CR) and partial response (PR) groups. HSP70 protein expression, tumor diameter and tumor volume were lower in the CR group than in the PR group. The rate of tumor shrinkage, relative positive enhancement integral (rPEI), relative maximum slope of decrease (rMSD), relative signal enhancement ratio at 60 s (rSER60) and maximum SER (rSERmax), mean apparent diffusion coefficient (ADC mean) and minimum ADC value (ADC min) values in the CR group were higher than those in the PR group. Tumour diameter and volume, rSER15 and rSER30 were reduced after chemoradiotherapy, while rMSD, rSERmax, time to peak (TTP), ADC mean and ADC min were higher after the treatment. The receiver operating characteristic (ROC) curves indicated that HSP70 expression, tumor diameter, rPEI, ADC mean and Cho peak showed the better chemoradiotherapy efficacy. Our data demonstrates that HSP70 protein combined with multimodal MRI may accurately evaluate the chemoradiotherapy efficacy of patients with advanced cervical cancer. The recurrence of cervical cancer significantly decreased in patients with negative expression of HSP70, and HSP70 protein detection provides potential therapy for the prevention, diagnosis, and prognosis of cervical cancer. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/jcb.26424

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