Jumping the Barrier: Modeling Drug Penetration Across the Blood-Brain Barrier.

4 years ago

Jumping the Barrier: Modeling Drug Penetration Across the Blood-Brain Barrier.

Figg, Peer, Chau

Determining the penetration of drugs across the blood-brain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically-based pharmacokinetic model can predict drug exposures in the brain without needing in situ drug measurements.

Publisher URL: http://doi.org/10.1158/1078-0432.CCR-17-2741

DOI: 10.1158/1078-0432.CCR-17-2741

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