Chemistry - A European Journal
Chemistry - A European Journal
4 years ago

Frontispiece: Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics

Frontispiece: Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics
Zhen Yu, James A. Cowan
Advances in the design and application of catalytic metallodrugs are highlighted in the Review by Z. Yu and J. A. Cowan on page 14113 ff., and approaches to the design of catalytic metallodrugs that selectively target a therapeutically relevant biomolecule are discussed. Incorporation of a recognition domain into catalytic metallodrugs improves substrate selectivity and many examples of catalytic metallodrugs that selectively inactivate or degrade nucleic acid, protein, or other biomolecular targets are described.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201785762

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