Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

5 years ago

Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

Dayang Wu, Guofang Zhou, Qing Li, Yang Xiao, Kun Yu, Guangqian Lan, Fangying Dai, Bitao Lu, Fei Lu

Silver inlaid with gold nanoparticles (Au–Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au–Ag NPs were loaded into chitosan as wound dressing (CS–Au–Ag). CS–Au–Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS–Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS–Au–Ag showed low cytotoxicity to L929 cells similar to CS–Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS–Au–Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS–Au–Ag greatly promoted wound healing compared to CS–Ag in vivo, demonstrating that CS–Au–Ag presents great potential for wound dressing, promoting wound healing.

Publisher URL: http://dx.doi.org/10.1021/acs.biomac.7b01180

DOI: 10.1021/acs.biomac.7b01180