ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces
4 years ago

Tuning the Endocytosis Mechanism of Zr-Based Metal–Organic Frameworks through Linker Functionalization

Tuning the Endocytosis Mechanism of Zr-Based Metal–Organic Frameworks through Linker Functionalization
Daniel Maspoch, Inhar Imaz, David Fairen-Jimenez, Ross S. Forgan, Gerard Boix, Ross J. Marshall, Salame Haddad, Isabel Abánades Lázaro, Claudia Orellana-Tavra
A critical bottleneck for the use of metal–organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an efficient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4′-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol and enhancing their therapeutic activity when loaded with drugs.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b07342

DOI: 10.1021/acsami.7b07342

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