4 years ago

Manipulating Cellular Activities Using an Ultrasound–Chemical Hybrid Tool

Manipulating Cellular Activities Using an Ultrasound–Chemical Hybrid Tool
Cuei-Ling Wang, Yu-Chun Lin, Albert Alexander Lee, Tsung-Shing Andrew Wang, Sheng-Yang Ho, Chih-Kuang Yeh, Yen-Ling Lian, Yao-Shen Huang, Yu-Lin Kao, Tasuku Ueno, Ching-Hsiang Fan, Wei-En Huang
We developed an ultrasound–chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.

Publisher URL: http://dx.doi.org/10.1021/acssynbio.7b00162

DOI: 10.1021/acssynbio.7b00162

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