ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces
5 years ago

Quantitatively Intrinsic Biomimetic Catalytic Activity of Nanocerias as Radical Scavengers and Their Ability against H2O2 and Doxorubicin-Induced Oxidative Stress

Quantitatively Intrinsic Biomimetic Catalytic Activity of Nanocerias as Radical Scavengers and Their Ability against H2O2 and Doxorubicin-Induced Oxidative Stress
Yongquan Qu, Dehui Xu, Yuan Gao, Yuanyuan Ma, Tao Chen, Bingchuan Wang, Xuhui Li, Zhimin Tian
Artificial enzymes as radical scavengers show great potentials in treatments of various diseases induced by oxidative stress. Herein, the quantitative analysis indicates that the intrinsic activity of nanocerias for the degradation of radicals is determined by the concentration of surface defects as well as their morphological features. The surface Ce3+ fraction of the CeO2 nanozymes with a similar morphology can be used as a descriptor to index their catalytic activity as radical scavengers. Defect-abundant porous nanorods of ceria (PN-CeO2) with a large surface area (141 m2/g) and high surface Ce3+ fraction (32.8%) deliver an excellent catalytic capability for the degradation of radicals, which is 15.5 times higher than that of Trolox. Results indicate that PN-CeO2 not only provides more surface catalytic centers but also supplies the active site with higher activity. Oxidative stress induced by doxorubicin (Dox), an essential medicine for a wide range of tumors, was used as the model system to evaluate the radical degradation ability of PN-CeO2. Both in vitro cellar (H9c2 cells) and in vivo animal models revealed that PN-CeO2 did not affect the cell and rat growth and was able to alleviate the Dox-induced oxidative stress. Results suggest that the artificial PN-CeO2 nanozymes have potentials to function as an adjuvant medicine during tumor chemotherapy.

Publisher URL: http://dx.doi.org/10.1021/acsami.7b04761

DOI: 10.1021/acsami.7b04761

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.