Chemistry - An Asian Journal
Chemistry - An Asian Journal
5 years ago

Rhodium(III)-Catalyzed Directed C−H Amidation of N-Nitrosoanilines and Subsequent Formation of 1,2-Disubstituted Benzimidazoles

Rhodium(III)-Catalyzed Directed C−H Amidation of N-Nitrosoanilines and Subsequent Formation of 1,2-Disubstituted Benzimidazoles
Lanting Xu, Qiujun Peng, Yanyu Chen, XianHua Pan, Rong Zhang
An efficient rhodium-catalyzed direct C−H amidation of N-nitrosoanilines with 1,4,2-dioxazol-5-ones as amidating agents has been developed. This method featured mild reaction conditions, a wide substrate scope and satisfactory yields. Besides, the amidated products could be readily converted to pharmaceutically valuable 1,2-disubstituted benzimidazoles via an HCl-mediated deprotection/cyclization process in one pot. Can't say NO to that! An efficient rhodium-catalyzed direct C−H amidation of N-nitrosoanilines with 1,4,2-dioxazol-5-ones as amidating agents and subsequent formation of 1,2-disubstituted benzimidazoles via a one-pot reaction has been developed.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201701287

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