3 years ago

Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors

Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
The embryonic origin of lineage precursors of the trunk dermis is somewhat controversial. Precursor cells traced by Myf5 and Twist2 (Dermo1) promoter activation (i.e., cells of presumed dermomyotomal lineage) have been reported to generate Schwann cells. On the other hand, abundant data demonstrate that dermal Schwann cells derive from the neural crest. This is relevant because dermal precursors give rise to neural lineages, and multilineage differentiation potential qualifies them as adult stem cells. However, it is currently unclear whether neural lineages arise from dedifferentiated Schwann cells instead of mesodermally derived dermal precursor cells. To clarify these discrepancies, we traced SOX2+ adult dermal precursor cells by two independent Myf5 lineage tracing strains. We demonstrate that dermal Schwann cells do not belong to the Myf5 + cell lineage, indicating that previous tracing data reflected aberrant cre recombinase expression and that bona fide Myf5 + dermal precursors cannot transdifferentiate to neural lineages in physiological conditions.

Graphical abstract

image

Teaser

In this article, Izeta, Gutiérrez-Rivera and colleagues solve a controversy regarding how non-neural crest-derived adult dermal precursors are able to commit to peripheral glial fate. Through Myf5 + cell lineage tracing (with two independent strains), in situ localization, and sorting experiments, they demonstrate that aberrant lineage tracing unexpectedly traces dermal Schwann cells. Thus, instead of resident stem/precursor cells, neural-competent cells of adult ventral dermis may just be dedifferentiated Schwann cells.

Publisher URL: www.sciencedirect.com/science

DOI: S2213671117304174

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.