Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Cobalt Catalysis for Enantioselective Cyclobutanone Construction

Cobalt Catalysis for Enantioselective Cyclobutanone Construction
Vy M. Dong, Raphael S. Kim, Jan Riedel, Daniel K. Kim
Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).

Publisher URL: http://dx.doi.org/10.1021/jacs.7b05327

DOI: 10.1021/jacs.7b05327

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