3 years ago

CuX-Activated N-Halosuccinimide: Synthesis of 3-Haloquinolines via Electrophilic Cyclization of Alkynyl Imines

CuX-Activated N-Halosuccinimide: Synthesis of 3-Haloquinolines via Electrophilic Cyclization of Alkynyl Imines
Jinzhong Yao, Hongwei Zhou, Le Liu, Qianshou Zong, Dianpeng Chen, Jianbo Wang
We report an electrophilic cyclization of alkynyl imines to afford polysubstituted 3-haloquinolines using CuX-activated N-halosuccinimdes (NXS) as electrophiles. Control experiments demonstrated that the NXS/CuX system might be more active than single NXS and could be applied in the electrophilic cyclization of electron- deficient substrates.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00131

DOI: 10.1021/acs.joc.7b00131

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