3 years ago

Structured models of cell migration incorporating molecular binding processes

Pia Domschke, Mark A. J. Chaplain, Dumitru Trucu, Alf Gerisch

Abstract

The dynamic interplay between collective cell movement and the various molecules involved in the accompanying cell signalling mechanisms plays a crucial role in many biological processes including normal tissue development and pathological scenarios such as wound healing and cancer. Information about the various structures embedded within these processes allows a detailed exploration of the binding of molecular species to cell-surface receptors within the evolving cell population. In this paper we establish a general spatio-temporal-structural framework that enables the description of molecular binding to cell membranes coupled with the cell population dynamics. We first provide a general theoretical description for this approach and then illustrate it with three examples arising from cancer invasion.

Publisher URL: https://link.springer.com/article/10.1007/s00285-017-1120-y

DOI: 10.1007/s00285-017-1120-y

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