4 years ago

A Preliminary Evaluation of Glial Cell Line-Derived Neurotrophic Factor (GDNF) Levels in Cerebrospinal Fluid Across Various Gestational Ages and Clinical Conditions of the Neonate

This study aims to investigate glial cell derived neurotrophic factor (GDNF) levels in newborns’ umbilical cord blood and cerebrospinal fluid across various perinatal growth parameters and clinical conditions. Methods Cord blood from 20 newborns and 58 residual CSF samples (stored after completion of clinical testing) were collected. GDNF levels were determined using GDNF ELISA kits from R&D Systems in triplicates with appropriate controls to eliminate background. Results Cord blood GDNF levels were significantly higher (p=0.004) in preterm newborns (n=6) (115.05±57.17,pg/ml) when compared to term newborns (n=14) (19.67±10.67,pg/ml). GDNF levels in CSF trended (p=0.07) higher in term newborns (n=10) (19.56±9.11,pg/ml) when compared to preterm newborns at term or post term corrected gestational ages (n=5) (14.49±3.53,pg/ml). CSF-GDNF levels in term newborn with post hemorrhagic hydrocephalus tended to increase with time while those in preterm newborns tended to decrease with time. Conclusions GDNF levels in preterm newborns were higher in cord blood and lower in CSF as compared to term newborns. In addition, preterm and term newborns with post hemorrhagic hydrocephalus had different trends of CSF-GDNF levels over time. It is important to further study circulating and CSF-GDNF levels in newborns at different gestational ages and clinical conditions.

Publisher URL: www.sciencedirect.com/science

DOI: S0736574817301466

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