ACS Catalysis
ACS Catalysis
5 years ago

Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide

Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide
Andrea Gandini, Milan Bera, Soumitra Agasti, Giuseppe Zanoni, Kapileswar Seth, Ashis Das, Debabrata Maiti, Massimo Brochetta, Alessio Porta
The use of unbiased aliphatic alkene as the coupling partner for C–H olefination continues to be a challenging task. A suitable chelating directing group allowed ortho C–H olefination of benzyl phosphonamide with unactivated aliphatic alkenes. The broad substrate scope with respect to variation of benzyl phosphonamides and aliphatic alkenes as well as examples of sequential hetero-bis-olefinations offer diversity along with excellent linear/branch selectivity.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02394

DOI: 10.1021/acscatal.7b02394

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