PLOS Genetics
PLOS Genetics
4 years ago

STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in <i>Drosophila</i>

Tin Tin Su, Shilpi Verghese
We report here a study of regeneration in Drosophila larval wing imaginal discs after damage by ionizing radiation. We detected faithful regeneration that restored a wing disc and abnormal regeneration that produced an extra wing disc. We describe a sequence of changes in cell number, location and fate that occur to produce an ectopic disc. We identified a group of cells that not only participate in ectopic disc formation but also recruit others to do so. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth. The picture that emerges is one in which activities like STAT increase after radiation damage and fulfill essential roles in rebuilding the tissue. But such activities must be kept in check so that one and only one wing disc is regenerated.

Publisher URL: http://journals.plos.org/plosgenetics/article

DOI: 10.1371/journal.pgen.1007055

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