3 years ago

Copper-Catalyzed Synthesis of Substituted 2,4-Diamino-1,3,5-triazines from 1,1-Dibromoalkenes and Biguanides

Copper-Catalyzed Synthesis of Substituted 2,4-Diamino-1,3,5-triazines from 1,1-Dibromoalkenes and Biguanides
Dong-Mei Cui, Chen Zhang, Shun-Na Guo, Zhen-Yu Luo, Kai Zhu, Li-Yu Zhang, Meng-Tao Ban, Yu Zhang
An efficient copper-catalyzed synthesis of substituted 2,4-diamino-1,3,5-triazines from 1,1-dibromoalkenes and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated alkyl-, heterocyclic-, or aryl-substituted 1,1-dibromoalkenes containing functionalities such as nitriles, ethers, and halogens. Monosubstituted to tetrasubstituted biguanidines also afforded the desired products.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01608

DOI: 10.1021/acs.orglett.7b01608

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