4 years ago

Long-term Outcomes of Ocular Surface Stem Cell Allograft Transplantation

To investigate the long-term outcomes of ocular surface stem cell allograft transplantation (OSST) in patients with total limbal stem cell deficiency (LSCD) due to various etiologies with a follow-up ≥ 5 years. Design Retrospective interventional cohort. Methods ▪▪▪ Setting Single tertiary referral hospital. Study population Patients who had (1) presence of total LSCD, (2) surgical treatment with at least one allograft OSST procedure, and (3) minimum follow-up ≥ 5 years after OSST. Intervention All patients underwent allograft OSST from March 1998 to June 2009. All patients received systemic immunosuppression. Main outcome measures Ocular surface stability, best-corrected visual acuity (BCVA) Results 165 eyes of 110 patients fulfilled the inclusion criteria with a mean follow-up period of 109.22 ± 35.7 months or approximately 9.1 years (range 5.2 to 17.7 years). Ocular surface stability was achieved in 72.7% (120/165) of eyes at last follow-up, while 15.2% (25/165) maintained an improved ocular surface and 12.1% (20/165) developed total surface failure. Additional OSST surgery was necessary in 30.9% (51/165 eyes) to maintain a stable ocular surface. There was a ≥ 2 lines BCVA improvement in 62.1%, no change in 7.7%, and a worsened BCVA in 18.6% at last follow-up. Conclusions With proper immunosuppression and repeat procedure in case of failure, allograft OSST can provide true long-term ocular surface stability and successful visual outcomes.

Publisher URL: www.sciencedirect.com/science

DOI: S0002939417304257

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.