4 years ago

Pregnancy-induced changes in corneal biomechanics and topography are thyroid hormone related

To identify biomechanical and topographical changes of the cornea during pregnancy and the postpartum period and its association to hormonal changes. Design Prospective single-center observational cohort study. Methods Participants: 24 pregnant women (48 eyes), monitored throughout pregnancy and after delivery. Biomechanical and topographical corneal properties were measured using the Ocular Response Analyzer (ORA) and a Scheimpflug imaging system (Pentacam HR) each trimester and 1 month after delivery. At the same consultations blood plasma levels of estradiol (E2) and thyroid hormones (TSH, T3t, T4t) were also determined. A factorial MANOVA was used to detect interactions between hormonal plasma levels and ocular parameters. Results Significant differences in corneal biomechanical and topographical parameters were found during pregnancy in relation to T3t (p=0.01), T4t (p<0.001), T3t/T4t (p=0.001) and TSH (p=0.001) plasma levels. E2 plasma levels (p=0.092) and time-period of measurement (p=0.975) did not significantly affect corneal parameters. TSH levels significantly affected the maximal keratometry reading (p=0.036), the vertical keratometry (p=0.04) reading and the index of height asymmetry (p=0.014). Those results persist after excluding hypothyroidism patients from the statistical analysis. Conclusions Hormonal changes affecting corneal biomechanics and topography during pregnancy could be thyroid-related. Dysthyroidism may directly influence corneal biomechanics and represents a clinically relevant factor that needs further investigation. Highlights Thyroid hormones may affect corneal shape and biomechanical properties more than estrogen.

Publisher URL: www.sciencedirect.com/science

DOI: S0002939417304245

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.