3 years ago

Targeted Family Intervention for Complex Cases of Pediatric Obsessive-Compulsive Disorder: A Randomized Controlled Trial

Although evidence-based treatments for pediatric obsessive-compulsive disorder (OCD) exist, many youth fail to respond, and interventions tailored to the needs of specific subsets of patients are lacking. This study examines the efficacy of a family intervention module designed for cases of OCD complicated by poor family functioning. Method Participants were 62 youngsters ages 8-17 (mean age = 12.71 years; 57% male; 65% Caucasian) with a primary diagnosis of OCD and at least two indicators of poor family functioning. They were randomized to receive 12 sessions of individual child cognitive-behavioral therapy (CBT) plus weekly parent psychoeducation and session review (standard treatment; ST) or the same 12 child sessions plus six sessions of family therapy aimed at improving OCD-related emotion regulation and problem-solving (Positive Family Interaction Therapy; PFIT). Blind raters evaluated outcomes and tracked responders to three-month follow-up. Results Compared to ST, PFIT demonstrated better overall response rates on the Clinician Global Impression-Improvement scale (CGI-I; 68% versus 40%, p = .03, phi = 0.28) and rates of remission (58% PFIT versus 27% ST, p = .01, phi = 0.32). PFIT also produced significantly greater reductions in functional impairment, symptom accommodation, and family conflict, and improvements in family cohesion. As expected, these shifts in family functioning constitute an important treatment mechanism, with changes in accommodation mediating treatment response. Conclusion PFIT is efficacious for reducing OCD symptom severity and impairment and for improving family functioning. Findings are discussed in terms of personalized medicine and mechanisms of change in pediatric OCD treatment. Clinical trial registration information Family Focused Treatment of Pediatric Obsessive Compulsive Disorder; http://clinicaltrials.gov/; NCT01409642.

Publisher URL: www.sciencedirect.com/science

DOI: S0890856717317768

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