Magnetic Resonance in Medicine
Magnetic Resonance in Medicine
3 years ago

Spatial resolution and velocity field improvement of 4D-flow MRI

Fraser M. Callaghan, Stuart M. Grieve
Purpose 4D-flow MRI obtains a time-dependent 3D velocity field; however, its use for the calculation of higher-order parameters is limited by noise. We present an algorithm for denoising 4D-flow data. Theory and Methods By integrating a velocity field and eliminating streamlines in noisy flow, depicted by high curvature, a denoised dataset may be extracted. This method, defined as the velocity field improvement (VFIT) algorithm, was validated in an analytical dataset and using in vivo data in comparison with a computation fluid dynamics (CFD) simulation. As a proof of principal, wall shear stress (WSS) measurements in the descending aorta were compared with those defined by CFD. Results The VFIT algorithm achieved a >100% noise reduction of a corrupted analytical dataset. In addition, 4D-flow data were cleaned to show improved spatial resolution and near wall velocity representation. WSS measures compared well with CFD data and bulk flow dynamics were retained (<2% difference in flow measurements). Conclusion This study presents a method for denoising 4D-flow datasets with improved spatial resolution. Bulk flow dynamics are accurately conserved while velocity and velocity gradient fields are improved; this is important in the calculation of higher-order parameters such as WSS, which are shown to be more comparable to CFD measures. Magn Reson Med 78:1959–1968, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mrm.26557

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