Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Development of a One-Pot Synthetic Method for Multifunctional Oxazole Derivatives Using Isocyanide Dichloride

Development of a One-Pot Synthetic Method for Multifunctional Oxazole Derivatives Using Isocyanide Dichloride
Akihiro Matsumoto, Yutaka Ukaji, Yoko Sakata, Takahiro Soeta
A one-pot synthetic method was developed for multifunctional dihydrooxazole and oxazole derivatives. New reaction sequences were developed involving the formation of isocyanide dichloride, an aldol-type reaction with aldehydes, and a nucleophilic addition–elimination reaction, which efficiently afforded the dihydrooxazole and oxazole scaffolds.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00296

DOI: 10.1021/acs.joc.7b00296

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