FEBS Letters
FEBS Letters
3 years ago

Nicotinic Acetylcholine Receptors in Neuropathic and Inflammatory Pain

J. Michael McIntosh, Arik J. Hone
Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic targets for the treatment of pain and inflammation, but despite more than 30 years of research, there are currently no FDA approved analgesics that target these receptors. Much of the initial research effort focused on the α4β2 subtype, but more recently, additional subtypes have been identified as promising new therapeutic targets and include α6β4, α7 and α9-containing subtypes. This Review will focus on the distribution of these nAChRs in the cell types involved in neuropathic pain and inflammation as well as current pharmacological compounds that target them. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/1873-3468.12884

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