4 years ago

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
Sarai Martínez-Cano, Michel Enamorado, Mariano Esteban, Elena Priego, Andrés Hidalgo, David Sancho, Ignacio Melero, Ernesto Mejías-Pérez, Juan A. Quintana, Francisco J. Cueto, Salvador Iborra
The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy.

Publisher URL: https://www.nature.com/articles/ncomms16073

DOI: 10.1038/ncomms16073

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