3 years ago

Occult hepatitis B infection: a hidden factor of poor response to intervention treatment of hepatocellular carcinoma in chronic hepatitis C patients

Hanan Omar, Wafaa Hassan, Hamdy Omar, Samaa Taha

Abstract

Hepatocellular carcinoma (HCC), a tumor associated with high mortality, has rising worldwide incidence. Occult hepatitis B (OBI) could influence the development of HCC with a strong association with HCV infection. The risk of tumor recurrence or poor response to treatment may be due to the presence of underlying cirrhosis with viral hepatitis. The aim of this study is to assess the prevalence of OBI among patients who are hepatitis B core antibody positive with chronic hepatitis C (CHC) having HCC and assess its impact on treatment response. A total of 240 patients with CHC who were negative for hepatitis B surface antigen (HBsAg) were enrolled. One hundred twenty patients were diagnosed to have HCC for which they underwent interventional treatment whereas 120 patients had no evidence of HCC. Hematological and biochemical tests, Anti-HBc IgG, and HBV-DNA were done. Prevalence of isolated Anti-HBc IgG and HBV DNA in their sera were 70 and 23.8% respectively in HCC patients, but only 43.3% and 15.4% respectively in CHC patients. Patients who tested positive for anti-HBc IgG had one and half times higher risk of having HCC when compared patients who tested negative. Majority (84.6%) of patients with HCC who were non-responders to interventional treatment tested positive for anti-HBc IgG, and 36% of them had detectable HBV DNA in their sera. HBV DNA(+) patient had two times higher risk of having poor response to HCC intervention treatment more than patients with serum HBV DNA(−). Previous exposure to HBV had a strong association with HCC in CHC patients, and OBI is an independent risk factor for poor response to intervention treatment of HCC.

Publisher URL: https://link.springer.com/article/10.1007/s00580-018-2735-0

DOI: 10.1007/s00580-018-2735-0

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.