3 years ago

Mechanisms of metformin action: In and out of the gut

Mechanisms of metformin action: In and out of the gut
Takahiro Minamii, Wataru Ogawa, Munenobu Nogami


Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of 18F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affects the handling of glucose in colon whereas the underlying mechanism and the significance to glucose metabolism of the finding remain to be determined.

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