Heart Rhythm
Heart Rhythm
4 years ago

Time course and interrelationship of dysrhythmias in patients with a surgically repaired atrial septal defect

Atrial fibrillation (AF) and other supraventricular tachycardias (SVT) are known complications after surgical repair of an atrial septal defect (ASD), but sinus node dysfunction (SND) and complete atrioventricular conduction block (cAVB) may also occur. Objective The aims of this study were to examine time course and interrelationship of various dysrhythmias in patients with an ASD. Methods Adult patients (N=95) with a surgically repaired secundum ASD (N=40), partial atrioventricular septal defect (N=37) or sinus venosus defect (N=18) and documented SND, cAVB, AF and/or other SVT were included. Median age at repair was 13 years (interquartile range 6–45) and patients were followed for 26 years (interquartile range 15–37) after ASD repair. Results SND was observed in 34 patients (36%), cAVB in 14 (14%), AF in 48 (49%) and SVT in 44 (45%); 37 (39%) patients had ≥2 dysrhythmias. All dysrhythmias presented most often after ASD repair (p<0.01) with a median duration of 12 to 16 years between repair and onset. Development of SND and cAVB late after ASD repair was not related to a redo procedure in respectively 100% and 60% of patients. SND preceded atrial tachyarrhythmias in 50% (p=0.31) and SVT preceded AF in 68% (p=0.09) of patients with both dysrhythmias. Conclusions A substantial number of dysrhythmias presented (very) late after ASD repair. In most patients, development of late SND and cAVB was not related to redo procedures. In patients with multiple dysrhythmias, a specific order of appearance was not observed.

Publisher URL: www.sciencedirect.com/science

DOI: S1547527117312134

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.