Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals
Simona Müller, Andrés García-Domínguez, Cristina Nevado
β,β-Disubstituted vinyl sulfones were obtained with complete regio- and stereocontrol in a multicomponent reaction involving alkynes, organoboronic acids, and sulfonyl chlorides in the presence of a nickel catalyst. The reaction proceeds via sulfonyl radicals generated in situ under mild reaction conditions. Running mild: Readily available alkynes, boronic acids, and sulfonyl chlorides can be combined in the presence of a Ni catalyst to produce β,β-disubstituted vinyl sulfones with complete regio- and stereocontrol. The reaction proceeds via sulfonyl radicals generated in situ under mild reaction conditions and with high functional-group tolerance.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704862

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