3 years ago

Vitamin D and Age-Related Macular Degeneration.

Garhöfer, Delcourt, Silva, Holz, Aslam, Minnella, Layana, Seddon, Leys, Souied
In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.

Publisher URL: http://doi.org/10.3390/nu9101120

DOI: 10.3390/nu9101120

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