Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry
5 years ago

Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)

Structural evidence for the covalent modification of FabH by 4,5-dichloro-1,2-dithiol-3-one (HR45)
Van Kelly, Alexander G. Ekstrom, Jon Marles-Wright, Dominic J. Campopiano, Scott L. Cockroft
Mass spectrometry and modelling shows the antimicrobial inhibitor 4,5-dichloro-1,2-dithiol-3-one (HR45) acts by forming a covalent adduct with the target [small beta]-ketoacyl-ACP synthase III (FabH). The 5-chloro substituent directs attack of the essential active site thiol (C112) via a Michael type addition elimination reaction mechanism.

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/JFXtkV1TCkY/C7OB01396E

DOI: 2017/OB/C7OB01396E

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