Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

5 years ago

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors

Anne Swartjes, Johannes Reynisson, Ivanhoe K. H. Leung, Brooke Kwai, Krunal Patel, Jonathan Sperry, Ram Bhusal, Ghader Bashiri

The enzymes isocitrate lyase (ICL) isoforms 1 and 2 are essential for Mycobacterium tuberculosis survival within macrophages during latent tuberculosis (TB). As such, ICLs are attractive therapeutic targets for the...

Publisher URL: http://feeds.rsc.org/~r/rss/MD/~3/zgDIV44zbE0/C7MD00456G

DOI: 2017/MD/C7MD00456G

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