3 years ago

Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet

Devin Koestler, John P. Thyfault, Colin McCoin, Michael A. Cooper, Dong Pei, Douglas E. Wright


1 New Findings

  • What is the central question of this study?

    Do peripheral sensory neurons metabolize fat‐based fuel sources, and does a ketogenic diet modify these processes?

  • What is the main finding and its importance

    We show that peripheral axons from mice fed a ketogenic diet respond to fat‐based fuel sources with reduced respiration and H2O2 emission compared with mice fed a control diet. These results add to our understanding of the responses of sensory neurons to neuropathy associated with poor diet, obesity and metabolic syndrome. These findings should be incorporated into current ideas of axonal protection and might identify how dietary interventions may change mitochondrial function in settings of sensory dysfunction.

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