3 years ago

Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet

Devin Koestler, John P. Thyfault, Colin McCoin, Michael A. Cooper, Dong Pei, Douglas E. Wright

Abstract

1 New Findings

  • What is the central question of this study?

    Do peripheral sensory neurons metabolize fat‐based fuel sources, and does a ketogenic diet modify these processes?

  • What is the main finding and its importance

    We show that peripheral axons from mice fed a ketogenic diet respond to fat‐based fuel sources with reduced respiration and H2O2 emission compared with mice fed a control diet. These results add to our understanding of the responses of sensory neurons to neuropathy associated with poor diet, obesity and metabolic syndrome. These findings should be incorporated into current ideas of axonal protection and might identify how dietary interventions may change mitochondrial function in settings of sensory dysfunction.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.