4 years ago

Recent trends in capillary electrophoresis for complex samples analysis: A review

Miguel Ángel Bello-López, Andreu Llobera, Rut M. Fernández-Torres, Juan A. Ocaña-Gonzalez, María Ramos-Payán
Capillary electrophoresis has been a continuously evolving analytical methodology since its first introduction in the 80s of the last century. The development of new CE separation procedures, the coupling of these systems to more sensitive and versatile detection systems and the advances in miniaturization technology have allowed the application of CE to the resolution of new and complex analytical problems, overcoming the traditional disadvantages associated with this method. In the present work, different recent trends in capillary electrophoresis and their application to the determination of high complexity samples (as biological fluids, individual cells, etc.) will be reviewed: capillary modification by different types of coatings, microfluidic CE and on-line microextraction CE. The main advantages and disadvantages of the different proposed approaches will be discussed with examples of most recent applications. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/elps.201700269

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