3 years ago

Electrochemical Interpretation of Propagation of the Change in the Membrane Potential Using the Goldman-Hodgkin-Katz Equation

Electrochemical Interpretation of Propagation of the Change in the Membrane Potential Using the Goldman-Hodgkin-Katz Equation
Y. Kitazumi, K. Kano, O. Shirai
Nerve conduction has been frequently explained by the Hodgkin-Huxley equation based on the flow of K+ and Na+ across the cell membrane. By considering the relation between the membrane potential and the membrane current based on the Goldman-Hodgkin-Katz equation, it becomes clear that the conventional analysis using the voltage-clamp method is not correct and that the hyperpolarization condition is artificially made. Taking into account the channel functions and the electronic properties, we suggested a new propagation mechanism. When the nerve cell is excited by an external stimulus, the ligand-gated channels at the synapse serve as an electric power source to propagate the change in the membrane potential to the synapse terminal along the axon and the voltage-gated channels at the axon locally assist the directional propagation along the axon.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/elan.201700368

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