Electroanalysis
Electroanalysis
4 years ago

Voltammetric Determination of Captopril on a Glassy Carbon Electrode Modified with Copper Metal-Organic Framework

Voltammetric Determination of Captopril on a Glassy Carbon Electrode Modified with Copper Metal-Organic Framework
Wellyton Silva Vasconcelos, Gilvaldo Gentil da Silva, Janaína Versiani dos Anjos, Severino Alves Junior, Madalena Carneiro da Cunha Areias
We report in this work, a new method for the determination of captopril by differential pulse voltammetry using a glassy carbon electrode modified with a copper metal-organic framework (H-Kust-1 or Cu3(BTC)2 or Cu-BTC), immobilized on the surface by a copolymer of acrylamide and sodium acrylate. This compound is detected by the formation of a copper(II)-captopril complex that is observed in an oxidation potential at ca. +0.28 V vs. Ag/AgCl. A linear dynamic range is obtained for a captopril concentration of 0.5 μM to 7.0 μM and the voltammetric response is highly reproducible within 3.52 % error. The sensitivity of 9.71±0.37 nA μM−1 and the limit of detection of 0.20±0.01 μM make this methodology highly applicable for practical applications. The determination of captopril in a commercial pharmaceutical sample showed a recovery of 93.3 %.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/elan.201700384

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